IISc researchers have found cholesterol present in cell membrane playing a central role in the two-step process of stabilising and binding together the pore-forming toxin Cytolysin A. On binding to cholesterol, the structure of the toxin protein that is bound to the cell membrane undergoes a change and is also stabilised. Cholesterol is also essential in holding together the molecules before the toxin forms the pore.
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Published by Prasad Ravindranath
Science Editor with @The_Hindu, Chennai, India.
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