Podcast: Blocking the entry of TB bacteria into host cells

Priya Kalra -1-OptimizedScientists from AIIMS, THSTI and IIT Indore have successfully been able to inhibit the entry of TB bacteria into host cells by using aptamer-based inhibitor that binds to the HupB protein found on TB bacteria cell surface.  The researchers are now trying to deliver the aptamer into the TB bacterial cell to inhibit the DNA-binding function of HupB. If successful, it will make the bacteria vulnerable to stresses inside host cells leading to their death.