Chitra Mandal of CSIR-Indian Institute of Chemical Biology has seven more papers with manipulated images

Chitra - J13 - 2

Dr. Chitra Mandal, a SERB Distinguished Fellow at the CSIR-Indian Institute of Chemical Biology, Kolkata has seven more papers with problematic images — manipulation and/or duplication. These papers have been listed on Pubpeer. With this, there are 35 problematic papers by Dr. Mandal.

The number of papers by Dr. Chitra Mandal, a SERB Distinguished Fellow at the CSIR-Indian Institute of Chemical Biology, Kolkata that have problems with images — manipulation and/or duplication — continues to be flagged on Pubpeer website.

Pubpeer website allows independent scientists to publish post-publication review of scientific papers.

Chitra - J13 - 3-OptimizedAlready, Dr. Mandal’s 28 papers have been listed on Pubpeer for image manipulation and/or duplication. And in the last four days another seven more papers have been added to the list, taking the total to 35 papers. A paper published last year in the journal Cell Death and Disease seems to have problems.

In two instances, the figures have been reused in two different papers. These papers also have images that have been manipulated. She is the corresponding author in six of the seven papers.

Problematic papers listed on Pubpeer website

1) O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia

Kankana Mukherjee, Anil Kumar Chava, Chandan Mandal, Sailendra Nath Dey, Bernhard Kniep, Sarmila Chandra, Chitra Mandal

Journal of Cellular Biochemistry (2008)

2) Mobilization of lymphoblasts from bone marrow to peripheral blood in childhood acute lymphoblastic leukaemia: role of 9-O-acetylated sialoglycoproteins

Suchandra Chowdhury, Chandan Mandal, Sayantani Sarkar, Arup Kumar Bag, Reinhard Vlasak, Sarmila Chandra, Chitra Mandal

Leukemia Research (2012)

3) Disease-associated glycosylated molecular variants of human C-reactive protein activate complement-mediated hemolysis of erythrocytes in tuberculosis and Indian visceral leishmaniasis

Waliza Ansar, Sumi Mukhopadhyay, SK. Hasan Habib, Shyamasree Basu, Bibhuti Saha, Asish Kumar Sen, CN. Mandal, Chitra Mandal

Glycoconjugate Journal (2009)

4) Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression

Rajdeep Chowdhury, Raghunath Chatterjee, Ashok K. Giri, Chitra Mandal, Keya Chaudhuri

Toxicology Letters (2010)

5) 9-O-acetylated GD3 triggers programmed cell death in mature erythrocytes

Kankana Mukherjee, Suchandra Chowdhury, Susmita Mondal, Chandan Mandal, Sarmila Chandra, Rupak K. Bhadra, Chitra Mandal

Biochemical and Biophysical Research Communications (2007)

6) Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells

Shalini Nath, Chhabinath Mandal, Uttara Chatterjee, Chitra Mandal

Cell Death and Disease (2018)

7) Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9

Biswajit Khatua, Kaushik Bhattacharya, Chitra Mandal

Journal of Leukocyte Biology (2012)

5 Thoughts

  1. Infect Immun. 2009 Jan 29. [Epub ahead of print]
    RETRACTED: Sialic acids, important constituents and selective recognition factors of Pseudomonas aeruginosa, an opportunistic pathogen.
    Khatua B1, Ghoshal A, Bhattacharya K, Mandal C, Crocker PR, Mandal C.
    Author information
    1
    Infectious diseases and Immunology Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata-700 032; College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

    PMID: 19103775

    DOI: 10.1128/IAI.01083-08

    Pubpeer: https://pubpeer.com/publications/D1911F60712E456C371E4409775E1C#2
    Reasons not given, but looks like image duplication.

  2. 2019 retraction for Chitra Mandal.
    1, PLoS One. 2012;7(7):e42361. doi: 10.1371/journal.pone.0042361. Epub 2012 Jul 31.
    8 comments on PubPeer (by: Peer 1, Unregistered Submission, Acanthometra Fusca, Pluchea Kelleri, Elisabeth M Bik, Hoya Camphorifolia)

    Sialoglycosylation of RBC in visceral leishmaniasis leads to enhanced oxidative stress, calpain-induced fragmentation of spectrin and hemolysis.
    Samanta S1, Ghoshal A, Bhattacharya K, Saha B, Walden P, Mandal C.
    Author information
    1
    Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.

    Pubpeer: https://pubpeer.com/publications/BBA1570F0E0528B668FB27F7195044

    2019 retraction.
    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224539

    Concerns have been raised about results reported in Figs 1F and 4C of this article [1]:

    In Fig 1F, a cell with aberrant morphology appears to be duplicated within the RBCVL (sensitized) panel, and a cell cluster in this panel appears similar to a cluster in the RBCVL (unsensitized) panel. The RBCVL (sensitized) and RBCVL (unsensitized) panels appear to include several cells and cell clusters that overlap with Fig 3B of [2]. Also, the RBCN (sensitized) panel appears to overlap with data reported in Fig 3A in [2]. The images including similar elements represent different experiments in [1] and [2].
    When levels are adjusted to visualize background details, background areas within lanes 1 and 11 of Fig 4C appear more similar than would be expected for independent results, although the bands are different in the two lanes.
    The authors commented that an error was made in preparing Fig 1F and they provided alternate data for the RBCN (sensitized) and RBCVL (both) panels. The image offered as a replacement for the RBCVL-sensitized panel included cells with aberrant morphologies that appear similar to cell images in the original figure and in Fig 3B of [2].

    The original images supporting results in Fig 4 are no longer available.

    The PLOS ONE Editors retract this article due to these unresolved concerns, which call into question the reliability of the results reported in Figs 1F and 4C.

    CM did not agree with the retraction. The other authors did not respond or could not be reached.

    Additionally, Fig 1F is excluded from this article’s [1] license because it reports material from [2], published 2007 [Elsevier Inc.], which is not offered under a CC-BY license. At the time of retraction, the article [1] was republished to note this exclusion in the Fig 1 legend and the article’s copyright statement.

    Reference
    1.Samanta S, Ghoshal A, Bhattacharya K, Saha B, Walden P, Mandal C (2012) Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis. PLoS ONE 7(7): e42361. https://doi.org/10.1371/journal.pone.0042361 pmid:22860118

    2.Mukherjee K, Chowdhury S, Mondal S, Mandal C, Chandra S, Bhadra RK, et al. (2007) 9-O-acetylated GD3 triggers programmed cell death in mature erythrocytes. Biochem Biophys Res Commun 362(3):651–7. https://doi.org/10.1016/j.bbrc.2007.08.048 pmid:17761143

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