JNCASR researchers have synthesised a molecule that shows high antibacterial activity against multidrug-resistant Acinetobacter baumannii. The molecule has no toxicity to human cells. It is effective against A. baumannii bacteria that is dormant as well. A novel molecule developed by chemically linking (conjugate) an amino acid (glycine) to a polymer has been found to possess … Continue reading JNCASR’s molecule effective against multidrug-resistant Acinetobacter baumannii
Biofilm
IIT Roorkee’s novel molecule effective against multi-drug resistant bacteria
A molecule identified by IIT Roorkee researchers exhibits broadspectrum bactericidal activity against multidrug-resistant bacteria. The molecule was found to be effective against persister bacteria as well. Screening a small-molecule library of about 11,000 compounds, researchers at the Indian Institute of Technology (IIT) Roorkee identified a potent molecule that exhibits broadspectrum bactericidal activity against multidrug-resistant bacteria … Continue reading IIT Roorkee’s novel molecule effective against multi-drug resistant bacteria
Delhi researchers find diabetic drug improves the efficacy of two TB drugs
Delhi researchers have identified a protein that is vital for the formation of biofilm by TB-causing bacteria and other bacterial species. Two FDA-approved drugs (acarbose and cyclosporine-A) bind to the protein and inhibit biofilm formation. The two drugs increased the effectiveness of isoniazid and ethambutol (first-line TB drugs) 2- and 4-fold respectively. Animal trials have … Continue reading Delhi researchers find diabetic drug improves the efficacy of two TB drugs
IISc’s potent molecules show promise for TB therapy
Scientists at the Indian Institute of Science (IISc) Bengaluru have developed two new, potent molecules that can severely impact the survival of mycobacteria, including Mycobacterium tuberculosis that causes TB. The results were published in the journal Antimicrobial Agents and Chemotherapy. Unlike most antibiotics that target the bacterial metabolism by aiming at the cellular components, the … Continue reading IISc’s potent molecules show promise for TB therapy
Indian researchers find a new bacterial target for drug development
Indian researchers have found a new target that can potentially be used for developing new antibiotics that will be effective against many bacteria. The new target is made of two proteins — which form a complex that is responsible for the formation of biofilm — that perform very important functions and are critical for bacterial … Continue reading Indian researchers find a new bacterial target for drug development
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