Explained: How lab-grown organoids can transform medicine

Researchers had used brain organoids to study how Zika virus affects brain development in the embryo and causes small-sized brain called microcephaly. This study would have been nearly impossible using human brain at the embryo stage for obvious ethical reasons. On October 21, at the Society for Neuroscience’s 49th meeting Neuroscience 2019 held in Chicago, … Continue reading Explained: How lab-grown organoids can transform medicine

NCCS finds dual mechanism that helps embryonic stem cells maintain pluripotency

NCCS researchers have found two mechanisms that turn off the expression of endocytosis-associated genes, thus helping the stem cells to maintain their pluripotency.  The dual mechanism functions in such a way that even if one mechanism fails, the other can function as a back-up. Understanding of the mechanism will be helpful in regenerative medicine using iPS cells. … Continue reading NCCS finds dual mechanism that helps embryonic stem cells maintain pluripotency

Hyderabad researchers grow miniature eyes using stem cells

Researchers at the Hyderabad-based L.V. Prasad Eye Institute (LVPEI) have successfully grown miniature eye-like organs that closely resemble the developing eyes of an early-stage embryo. The miniature eyes were produced using induced pluripotent stem (iPS) cells. The iPS cells are produced by genetically manipulating human skin cells to produce embryonic-like stem cells that are capable … Continue reading Hyderabad researchers grow miniature eyes using stem cells

A step closer to regenerative medicine

A landmark study published today (September 12, 2013) in Nature shows that reprogramming of adult cells that behave like stem cells can be achieved right inside the body (in vivo). Till now, reprogramming of adult cells has been achieved only in labs (in vitro). This opens a promising window to repairing tissues right inside the … Continue reading A step closer to regenerative medicine

Editorial: Food for thought

At €2,50,000, the burger produced recently using meat cultured in a lab is probably the world’s most expensive sandwich. But it marks a major milestone in the long pursuit by a few scientists to grow meat in vitro. The small piece of meat containing 20,000 strips of muscle tissue, each one mm thick by 2.5 … Continue reading Editorial: Food for thought

“Functional” blood vessels made from stem cells

A team of scientists has been able to engineer “stable and functional” blood vessels in mice using induced pluripotent stem (iPS) cells taken from humans. The blood vessels lasted for 280 days in the brain of the mice. The scientists are from Massachusetts General Hospital, Boston, and Harvard Stem Institute, Harvard University. The skin cells … Continue reading “Functional” blood vessels made from stem cells

Editorial: Organs, made to order

Producing fully functional human organs using induced pluripotent stem cells (iPS cells) will, in the foreseeable future, cease to remain in the realm of science fiction. In a game-changing study published recently in Nature, a team of Japanese scientists led by Takanori Takebe from the Yokohama City University Graduate School of Medicine has taken a … Continue reading Editorial: Organs, made to order

Editorial: Fear unfounded

With Britain recently deciding to proceed with draft regulations on the mitochondria replacement technique for preventing women from transmitting mitochondrial disorders to their children, the method joins the list of revolutionary fertility and embryology tools that have come under opposition and criticism. In the recent past, the somatic cell nuclear transfer (SCNT) method has faced … Continue reading Editorial: Fear unfounded

Editorial: Turning the clock back

Published in The Hindu on October 10,2012 The Nobel Prize in Physiology or Medicine awarded on Monday to Sir John B. Gurdon of the Gurdon Institute in Cambridge and Dr. Shinya Yamanaka from Kyoto University for their path-breaking discoveries was not unexpected. Dr. Yamanaka had won two other prestigious science awards — the Albert Lasker … Continue reading Editorial: Turning the clock back

Repairing damaged hearts by healing affected cells

Published in The Hindu on April 19, 2012 Scientists have found an easier way of repairing hearts damaged by cardiac arrest — reprogramming one kind of heart cells into another. A paper published today (April 19) in Nature details how the remarkable feat of reprogramming cardiac fibroblasts into adult cardiac muscle-like cells (cardiomyocyte) produced promising … Continue reading Repairing damaged hearts by healing affected cells