Moderna, Pfizer vaccines neutralise variants encoding mutations E484K or N501Y but with less potency

The neutralisation by 14 of the 17 most potent antibodies was reduced or abolished by either K417N, or E484K, or N501Y mutations in sera of people vaccinated with Moderna or Pfizer vaccine. In a small cohort involving just 20 trial participants, researchers have found that both Moderna and Pfizer-BioNTech are able to neutralise SARS-CoV-2 variants … Continue reading Moderna, Pfizer vaccines neutralise variants encoding mutations E484K or N501Y but with less potency

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ACTREC’s automated tool makes SARS-CoV-2 genome mutation analysis easy

The IPD tool can automatically determine the abundance of SARS-CoV-2 genome sequences, carry out mutation analysis with respect to the Wuhan sequence and finally based on the mutations seen in each sample assign it to the respective phylogenetic clade. Assigning a sample to a phylogenetic clade is based on the complete profile of mutations seen … Continue reading ACTREC’s automated tool makes SARS-CoV-2 genome mutation analysis easy

N501Y mutation in SARS-CoV-2 virus causes increased infectivity, disease severity in mice

Chinese researchers found N501Y mutation in a mouse-adapted SARS-CoV-2 virus strain. In the mouse model, the N501Y mutation was found to increase the binding affinity of the virus with the mouse ACE2 receptor. The mutation in the mouse-adapted strain also caused increased virulence. In a preliminary report posted on December 19, Dr. Andrew Rambaut from … Continue reading N501Y mutation in SARS-CoV-2 virus causes increased infectivity, disease severity in mice