IISc: HIV drug elvitegravir lowers the efficiency of immune system

The HIV drug elvitegravir shows significant inhibition in binding and cleavage of human DNA thereby causing distinct impairment of the immune system at higher concentration. A 3-fold reduction in immune activity is seen at 100 nM concentration and 8-fold reduction at 1,000 nM. In 70% of mice studied, the mature B cells responsible for immunity showed a reduction. … Continue reading IISc: HIV drug elvitegravir lowers the efficiency of immune system

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Nandita: Deaf but not out

When she woke up after a short afternoon nap on November 22, 2013, two days after her 24th birthday, Nandita Venkatesan could see her mother and brother talking to her but could understand nothing; she could hear sounds but could not comprehend them. The noisy world around her almost fell silent. Her hearing loss was … Continue reading Nandita: Deaf but not out

When pills make us worse: Monitoring the adverse effects of medicines

By Debaleena Basu A healthy 21-year-old youth was admitted to a hospital for an elective surgery. All preoperative physiological parameters were normal. On the surgery day, the commonly used drug bupivacaine was administered to induce spinal anaesthesia. Following the injection, he immediately went into shock. His blood pressure dropped, pulse weakened, and his breathing became … Continue reading When pills make us worse: Monitoring the adverse effects of medicines