Presence of colistin-resistant bacteria of food origin in the gut is cause for worry

A small study has found evidence of colistin-resistant bacteria in the gut. 77% of such bacteria were found to be food-acquired. There is a possibility of colistin resistant food Klebsiella to spread to human Klebsiella in the gut. A small study involving 65 stool samples taken from patients from a single hospital in Chennai found … Continue reading Presence of colistin-resistant bacteria of food origin in the gut is cause for worry

IMTECH’s novel compound treats colistin-resistant bacteria

A novel compound isolated from a soil bacterium by IMTECH researchers shows promise in killing Gram-negative bacteria (Klebsiella pneumoniae and E. coli) that are resistant to colistin. Compared with colistin, 16 times less of the compound is enough to kill colistin-resistant bacteria. The compound also resists spontaneous mutation. A novel compound isolated from a soil … Continue reading IMTECH’s novel compound treats colistin-resistant bacteria

Podcast: How Klebsiella bacteria develop colistin resistance

  Abdul Ghafur explains how the team deciphered the mechanism by which Klebsiella bacteria develop resistance to colistin, a last-line antibiotic. Mutations and insertional inactivation of the mgrB gene, which is present in the chromosome, are responsible for colistin resistance in Klebsiella. The inserational sequence that moves out from the chromosome to plasmid before spreading to other … Continue reading Podcast: How Klebsiella bacteria develop colistin resistance

Mechanism of colistin resistance in food Klebsiella bacteria unravelled

Researchers found colistin-resistant bacteria in 49% vegetable, meat samples in Chennai. They have for the first time deciphered the mechanism by which food Klebsiella bacteria develop resistance to colisitin, a last-line antibiotic. Mutations and insertional inactivation of the mgrB gene, which is present in the chromosome, are responsible for colistin resistance in Klebsiella. A study carried out in … Continue reading Mechanism of colistin resistance in food Klebsiella bacteria unravelled

Mcr-1 gene found in second human sample in the U.S.

Researchers have identified a second sample of E. coli in human sample in the U.S. containing the mcr-1 gene. This comes nearly six weeks after the first case of a 49-year-old woman from Pennsylvania with a urinary tract infection caused by E. coli was found carrying the gene, mcr-1.  Mcr-1 is resistant to the antibiotic colistin, the … Continue reading Mcr-1 gene found in second human sample in the U.S.

Will mcr-1 gene cause a new superbug?

Alarm bells have been sounded after a woman in the U.S. was detected with bacteria resistant to a last-resort antibiotic. The 49-year-old was carrying E. coli bearing a new gene, mcr-1, which is resistant to colistin, the last available antibiotic that works against strains that have acquired protection against all other medication. This is the … Continue reading Will mcr-1 gene cause a new superbug?