IACS fabricates hydrogels with tunable bactericidal activities

IACS researchers have fabricated a cytidine-based hydrogel that self-assembles in the presence of silver acetate and boronic acid and exhibits antibacterial activity against Gram-negative bacteria. The hydrogel can be used for drug delivery applications by using external stimuli such as mechanical stress or by changing the pH. Researchers at the Indian Association for the Cultivation … Continue reading IACS fabricates hydrogels with tunable bactericidal activities

IIT Hyderabad: A step closer to oral administration of Kala-azar drug

Using a novel drug-delivery approach, IIT Hyderabad researchers have made oral administration of the drug Amphotericin B for treating Kala-azar and fungal infection possible. The drug encapsulated in polymer nanofibres and made into tablets was released in a controlled and sustained manner for 10 days. By encapsulating an antifungal drug in polymer nanofibres, researchers at … Continue reading IIT Hyderabad: A step closer to oral administration of Kala-azar drug

IIT Guwahati uses water-repelling cotton for sustained drug release

IIT Guwahati researchers have used extremely water-repelling cotton for sustained drug release lasting as long as 110 days. In moderately water-repelling cotton, the drug is released over 50 days. Two drugs — aspirin and tetracycline — were tested for sustained drug release. The released drug was able to kill pathogenic bacteria. Sustained release of drugs … Continue reading IIT Guwahati uses water-repelling cotton for sustained drug release

Now, IISc team directly delivers protein into cells

By substituting a hydrogen atom of the protein with an iodine atom, IISc researchers have been successful in directly delivering proteins into mammalian cells. As a result, there was nearly six-fold increase in green fluorescent protein uptake by the cells. Supplementing the cellular protein becomes important during diseased conditions. In a breakthrough which might have huge … Continue reading Now, IISc team directly delivers protein into cells

IISc team uses iodine to increase cellular uptake of fluorescent probe

IISc researchers have drastically improved (up to 98%) the cellular uptake of fluorescent probe naphthalimide by substituting two of its hydrogen atoms with iodine. The iodine atom forms a halogen bond with the MCT8 receptor that ferries the molecule across the cell membrane. The probe molecule with iodine will also help in studying the uptake of thyroid hormone. By … Continue reading IISc team uses iodine to increase cellular uptake of fluorescent probe

Podcast: Drug loaded in nanovesicles improves cancer drug delivery

IISER Pune researchers have increased the uptake of poorly water-soluble anticancer drug by loading it in nanovesicles that self-assemble. The nanovesicles can be loaded with both hydrophilic and hydrophobic drugs. The encapsulated drug produced 94% silencing of the target AURKA leading to 25% inhibition of RalA. As a result, there was 38% inhibition of anchorage independent growth … Continue reading Podcast: Drug loaded in nanovesicles improves cancer drug delivery

IISER Pune team uses nanovesicles to improve cancer drug delivery

IISER Pune researchers have increased the uptake of poorly water-soluble anticancer drug by loading it in nanovesicles that self-assemble. The nanovesicles can be loaded with both hydrophilic and hydrophobic drugs. The encapsulated drug produced 94% silencing of the target AURKA leading to 25% inhibition of RalA. As a result, there was 38% inhibition of anchorage independent … Continue reading IISER Pune team uses nanovesicles to improve cancer drug delivery

IIT Hyderabad develops novel skin patch for constant drug release

A novel drug-delivery system that releases drug at constant rate for extended periods has been developed by IIT Hyderabad researchers. The transdermal patch made of patterned nanofabric and loaded with a pain killer (diclofenac sodium) with half-life of just one-two hours has been made to release for 12 hours at a constant rate. Researchers at the Indian Institute … Continue reading IIT Hyderabad develops novel skin patch for constant drug release

IIT teams use plant extract, heat to kill skin cancer cells

On being irradiated with near infrared light the dye gets heated up and facilitates the release of the extract from polymer membrane. After 4-5 minutes of irradiation about 80% of cancer cells were killed by both enhanced ROS generation inside cancer cells and by photothermal ablation. Nanoparticle formulation of a chlorophyll-rich biomolecular extract of an … Continue reading IIT teams use plant extract, heat to kill skin cancer cells

IISER Pune researchers produce a novel drug-delivery system to kill cancer cells

Researchers at the Indian Institute of Science Education and Research (IISER) Pune have developed a novel cancer drug-delivery system using graphene oxide nanoparticles. In a serendipitous discovery, a team led by Dr. Sudipta Basu and Dr. Nirmalya Ballav from the Department of Chemistry found that when a FDA-approved anticancer drug cisplatin was added, the graphene … Continue reading IISER Pune researchers produce a novel drug-delivery system to kill cancer cells