WHO's Solidarity Therapeutics Trial, the largest randomised control trial carried out in the world during the pandemic, has found that four repurposed drugs — remdesivir, interferon, hydroxychloroquine and lopinavir/ritonavir regimes — for the treatment of COVID-19 are not effective. WHO's Solidarity Therapeutics Trial, the largest randomised control trial carried out in the world during the … Continue reading Remdesivir, other repurposed drugs ineffective, says WHO’s Solidarity trial
Drug repurposing
Malarial drug effective for Zika virus treatment, IIT Mandi finds
IIT Mandi team has found that the FDA-approved drug for malaria (hydroxychloroquine or HCQ) binds to the protease enzyme of the Zika virus and stops the virus from replicating and surviving. When tested on placental cells infected with Zika virus, the malarial drug significantly reduced the viral load. Since the drug is approved for use … Continue reading Malarial drug effective for Zika virus treatment, IIT Mandi finds
Delhi researchers find diabetic drug improves the efficacy of two TB drugs
Delhi researchers have identified a protein that is vital for the formation of biofilm by TB-causing bacteria and other bacterial species. Two FDA-approved drugs (acarbose and cyclosporine-A) bind to the protein and inhibit biofilm formation. The two drugs increased the effectiveness of isoniazid and ethambutol (first-line TB drugs) 2- and 4-fold respectively. Animal trials have … Continue reading Delhi researchers find diabetic drug improves the efficacy of two TB drugs
Science Chronicle 