By turning to crystal engineering, the NCL-led team of researchers has improved the physical stability and bioavailability of a fixed-dose combination (FDC) drug containing four first-line anti-TB medicines. Cocrystal of isoniazid with caffeic acid showed five times better physical stability and bioavailability. The physical stability and bioavailability of a fixed-dose combination (FDC) drug containing four anti-TB … Continue reading NCL-led team improves stability, bioavailability of FDC drug for TB
Fixed dose combinations drugs
A looming threat of tuberculosis in children
The RNTCP guidelines on contact screening are heeded mostly in the breach. About 5,500 of over 76,000 children tested in nine Indian cities have been diagnosed with tuberculosis, 9% of them with multidrug-resistant TB (MDR-TB), highlighting the silent spread of the disease. Though the actual prevalence of MDR-TB among children in India is not known, … Continue reading A looming threat of tuberculosis in children
Drug resistance: The antibiotic red line of control
A much-needed public awareness campaign to highlight the dangers of misuse and irrational use of antibiotics was recently launched by the Ministry of Health and Family Welfare. Called ‘Medicines with the Red Line’, it comes at a time when the consumption of antibiotics in India has increased sharply while the effectiveness of these drugs to … Continue reading Drug resistance: The antibiotic red line of control
India flooded with unsafe drug combinations
Millions of unapproved formulations and products of fixed dose combinations (FDCs) available in India in three therapeutic areas — analgesia, anxiety/depression and psychosis — are unsafe and at times dangerous or even lethal, as in the case of anti-psychotic. In contrast, 98 per cent of metformin FDCs to treat diabetes has been approved by the … Continue reading India flooded with unsafe drug combinations
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