JNCASR researchers have synthesised a molecule that shows high antibacterial activity against multidrug-resistant Acinetobacter baumannii. The molecule has no toxicity to human cells. It is effective against A. baumannii bacteria that is dormant as well. A novel molecule developed by chemically linking (conjugate) an amino acid (glycine) to a polymer has been found to possess … Continue reading JNCASR’s molecule effective against multidrug-resistant Acinetobacter baumannii
Multidrug resistance
IIT Roorkee’s novel molecule effective against multi-drug resistant bacteria
A molecule identified by IIT Roorkee researchers exhibits broadspectrum bactericidal activity against multidrug-resistant bacteria. The molecule was found to be effective against persister bacteria as well. Screening a small-molecule library of about 11,000 compounds, researchers at the Indian Institute of Technology (IIT) Roorkee identified a potent molecule that exhibits broadspectrum bactericidal activity against multidrug-resistant bacteria … Continue reading IIT Roorkee’s novel molecule effective against multi-drug resistant bacteria
IISER Pune identifies druggable targets for multidrug-resistant Staphylococcus aureus
IISER Pune researchers have identified novel drug targets to kill multidrug-resistant Staphylococcus aureus. They increased the small molecule's ability to cross the cell barrier and bind to multiple proteins. A few proteins are crucial for bacteria's survival. Novel protein targets that can be used by candidate drug molecules to kill antibiotic-resistant strains of Staphylococcus aureus, … Continue reading IISER Pune identifies druggable targets for multidrug-resistant Staphylococcus aureus
Cheap, filter-based kits developed for TB diagnosis, drug-resistance testing
Three cheap, filter-based kits developed by a multi-institutional team and an industry partner improves the sensitivity of LED fluorescence microscopy by 5%, enable transport of sputum samples at ambient conditions without bio-safe containers and TB drug-resistance testing using molecular methods. To address the TB diagnostic challenges, a multi-institutional team has developed three cost-effective kits that … Continue reading Cheap, filter-based kits developed for TB diagnosis, drug-resistance testing
Cholera bacteria from India show high drug-resistance
The 443 cholera-causing Vibrio cholerae isolates isolated from patients from Kolkata and Delhi show very high drug resistance to 22 antibiotics belonging to nine classes. About 99% of the isolates are resistant to more than two antibiotics, 17% to more than 10 antibiotics, and 7.5% to more than 14 antibiotics. A study of 443 clinical … Continue reading Cholera bacteria from India show high drug-resistance
IMTECH’s novel compound treats colistin-resistant bacteria
A novel compound isolated from a soil bacterium by IMTECH researchers shows promise in killing Gram-negative bacteria (Klebsiella pneumoniae and E. coli) that are resistant to colistin. Compared with colistin, 16 times less of the compound is enough to kill colistin-resistant bacteria. The compound also resists spontaneous mutation. A novel compound isolated from a soil … Continue reading IMTECH’s novel compound treats colistin-resistant bacteria
Multidrug-resistant microbe repository to come up at NCCS
NCCS will soon start receiving and preserving multidrug-resistant bacteria and fungi from across the country. A decision is yet to be taken on microbes resistant to which antibiotics should be accepted. Samples collected from across the country will reveal how MDR microbes spread and evolve with time. Soon, the Pune-based National Centre for Cell Science (NCCS) … Continue reading Multidrug-resistant microbe repository to come up at NCCS
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