That scientists who pioneered the revolutionary CRISPR-Cas9 gene-editing technology, the biggest game-changer in biology in recent years, will win the Nobel Prize was never in doubt; it was only a question of when and who would get recognised for the work done to develop the tool.
CRISPR-Cas9
IGIB finds a protein with better gene editing precision
IGIB researchers have used a different Cas9 protein derived from another bacteria to make gene editing more efficient and precise. The new Cas9 protein shows very less tendency to bind to off-target (unintended) sites on DNA. The new Cas9 protein was able to correct sickle cell anaemia mutation in patient-derived stem cells. Researchers at the Delhi-based … Continue reading IGIB finds a protein with better gene editing precision
Explainer: Why is China laying down gene editing rules?
Dr. He’s experiment violates the 2003 guidelines that prohibits the use of gene-manipulated embryos for reproductive purposes. China has posted the draft regulation requiring researchers to obtain prior approval from the government before undertaking clinical trials. It is now all set to introduce the gene-editing regulation. In a bid to make babies immune to infection … Continue reading Explainer: Why is China laying down gene editing rules?
The promise of CRISPR
In a first, researchers from the Oregon Health and Science University along with colleagues in California, China and South Korea repaired an error in the DNA sequence (mutation) in human embryos by using a gene-editing tool called CRISPR-Cas9. The mutation seen in the MYBPC3 gene causes a common heart condition called hypertrophic cardiomyopathy, which is … Continue reading The promise of CRISPR
Scientists edit a disease-causing mutation from genes in human embryos
As scientists repair a genetic mutation in a human embryo, the ethical debate has been revived. Scientists have for the first time managed to edit genes in a human embryo to repair a genetic mutation, fuelling hopes that such procedures may one day be available outside laboratory conditions. In results announced in Nature a few days … Continue reading Scientists edit a disease-causing mutation from genes in human embryos
First CRISPR trial on humans set to begin
On June 21, the National Institutes of Health gave permission for starting the first ever clinical trial using CRISPR genome-editing technology, Nature news notes. The trial, which will begin before the end of the year, will be carried out on 18 cancer patients to “help augment cancer therapies that rely on enlisting a patient’s T … Continue reading First CRISPR trial on humans set to begin
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