IIT Hyderabad fabricates device for early diagnosis of heart attack

IIT Hyderabad researchers have fabricated a a microfluidic device that can detect cardiac biomarker cardiac troponin I over a wide range. The microfluidic device can detect the biomarker even when its concentration is as low as 0.005 nanogram per ml. A cardiac biomarker — cardiac troponin I — that is widely used for early diagnosis … Continue reading IIT Hyderabad fabricates device for early diagnosis of heart attack

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A large study measures blood biochemical parameters of Indian adolescents

The blood biochemical parameters —  lipid profile (total cholesterol, LDL, HDL and triglycerides), plasma glucose, insulin, HbA1c, urea, and creatinine — of Indian adolescents were measured in a large study involving over 7,600 subjects. This can now be used as reference for Indian adolescents. Till now, since biochemical parameters for Indian adolescents were not available, … Continue reading A large study measures blood biochemical parameters of Indian adolescents

Majority of MDR-TB cases in India due to direct transmission: Lancet

While India has set a highly ambitious target of “eliminating TB by 2025”, modelling studies published today say incidence and mortality will reduce by just 57% and 72% respectively by 2035. Ten percent of people with TB die or self-cure before presenting for care. Patient delay before first presentation for care is 4.1 months. Majority … Continue reading Majority of MDR-TB cases in India due to direct transmission: Lancet

IIT Hyderabad’s device detects heart attack early

IIT Hyderabad researchers have fabricated a low-cost, ultra-sensitive device that is capable of detecting the cardiac biomarker troponin T protein. Compared with the current limit of detection, the bioelectrode was able to detect troponin T even when it is 10,000 times less in concentration. A low-cost, ultra-sensitive device that is capable of detecting the cardiac biomarker … Continue reading IIT Hyderabad’s device detects heart attack early

IIT Roorkee identify salivary protein biomarkers of breast, ovarian cancer metastasis

IIT Roorkee researchers have identified certain proteins found in saliva that can be used as potential biomarkers indicative of breast and ovarian cancer metastasis. The composition and expression of salivary gland-derived proteins are altered in people with breast and ovarian cancer. So studying the salivary proteins may offer an easy alternative for screening cancer patients. … Continue reading IIT Roorkee identify salivary protein biomarkers of breast, ovarian cancer metastasis

CCMB develops paper-based device to determine lipid profile

CCMB researchers have fabricated a paper-based microfluidic device for rapid determination of lipid profile. Cholesterol and triglycerides can be detected in less than eight minutes and only 10 microlitre of serum sample is needed. The device has to be validated with more blood samples. A portable, cheap, point-of-care diagnostics for rapid determination of total cholesterol, … Continue reading CCMB develops paper-based device to determine lipid profile

IIITD-AIIMS team’s model can predict shock 12 hours in advance

A team led by IIITD-AIIMS researchers has developed a machine-learning algorithm to detect and predict shock using a single photo captured through thermal imaging. It has the ability to predict shock with 69% accuracy 12 hours before it can be clinically recognised by doctors using the current gold standard. The researchers plan to deploy it … Continue reading IIITD-AIIMS team’s model can predict shock 12 hours in advance

Podcast: New diagnostic tests for TB

Tarun Sharma explains how the team developed highly sensitive and specific diagnostic tests for pulmonary TB and pleural TB. The diagnostic tests make use of a DNA aptamer that shows high binding affinity to a TB antigen. The sensitivity for pulmonary TB and pleural TB was 94% and 93% respectively. And specificity was 100% for pulmonary … Continue reading Podcast: New diagnostic tests for TB

AIIMS-led team develops sensitive diagnostic tests for TB

Researchers have developed highly sensitive and specific diagnostic tests for pulmonary TB and pleural TB. The diagnostic tests make use of a DNA aptamer that shows high binding affinity to a TB antigen. Sputum samples were used for diagnosing pulmonary TB while pleural fluid was used for diagnosing pleural TB. A highly sensitive diagnostic test for … Continue reading AIIMS-led team develops sensitive diagnostic tests for TB

Podcast: Ten-year journey to develop a diagnostic test for TB meningitis

A team lead by Jaya Sivaswami Tyagi from AIIMS in collaboration with THSTI has developed a diagnostic test for TB meningitis with nearly 100% sensitivity and about 91% specificity. The rapid, point-of-care diagnostic test for TB meningitis, which uses the DNA aptamer, has already been adapted to a sensor format and is being evaluated on clinical samples. … Continue reading Podcast: Ten-year journey to develop a diagnostic test for TB meningitis