Rheumatoid arthritis: CDRI’s peptide effective in preventing cartilage destruction

CDRI researchers have used a specific fragment of a protein secreted by the parasitic worm liver fluke to protect the cartilage of joints from being destroyed, thus preventing rheumatoid arthritis from progressing. The peptide does not cause a wholesale suppression of the immune system. A specific fragment of a protein secreted by the parasitic worm … Continue reading Rheumatoid arthritis: CDRI’s peptide effective in preventing cartilage destruction

IIT Guwahati’s bone graft aids extensive bone formation

IIT Guwahati’s scaffold made of silk-bone cement composite doped with silicon and zinc metal ions has been found to extensively regenerate new bone tissue and blood vessels in rabbits in three months. At the end of three months, silk fibre gets degraded, bone cement gets absorbed, while silicon and zinc get leached out. The team is now … Continue reading IIT Guwahati’s bone graft aids extensive bone formation

IIT researchers 3D bioprint load-bearing bones

Researchers from IIT Delhi and IIT Kanpur have used a different approach to mimic the development biology pathway by which adult load-bearing bones are formed. The researchers made the stem cells to first differentiate into cartilage, and the cartilage was then converted into bones. The bones tissue engineered showed more similarity to limb skeleton development … Continue reading IIT researchers 3D bioprint load-bearing bones

Podcast: Making bone marrow transplantation more successful

Vaijayanti Kale from NCCS explains how micro-vesicles containing certain factors increase homing and engraftment potential of hematopoietic stem cells. These micro-vesicles also help in expanding hematopoietic stem cells before transplantation. The micro-vesicles are secreted by mesenchymal stem cells when treated with a nitric oxide donor.

NCCS’ new approach makes bone marrow transplantation more successful

NCCS researchers have found a way to expand hematopoietic stem cells before transplantation and also improve the engraftment potential. Mesenchymal stem cells treated with a nitric oxide donor secreted micro-vesicles containing certain factors that increase the engraftment potential of hematopoietic stem cells. One of the reasons why the efficiency of bone marrow transplantation gets compromised is due to … Continue reading NCCS’ new approach makes bone marrow transplantation more successful

Podcast: Fabricating a scaffold for cartilage repair

Yogendra Pratap Singh from IIT Guwahati explains how the biphasic scaffold fabricated using silk is superior to the existing ones. Since the entire scaffold is made of silk, the junction between the half that is spongy and mimics the cartilage while the other half is less porous and mimics the bone is seamless. In rabbits, … Continue reading Podcast: Fabricating a scaffold for cartilage repair

IIT Guwahati fabricates superior scaffold for cartilage repair

Using silk, researchers from IIT Guwahati have fabricated a biphasic scaffold where one half is spongy and mimics the cartilage while the other half is less porous and mimics the bone. The junction between the two phases is seamless. In rabbits, the fibre-reinforced scaffold allowed more bone formation, while the cartilage was regenerated and completely … Continue reading IIT Guwahati fabricates superior scaffold for cartilage repair

IIT Guwahati develops silk scaffold for bone regeneration

IIT Guwahati researchers have developed a scaffold made of silk composite functionalised with copper-doped bioactive glass. The scaffold facilitates faster and better bone regeneration, facilitates growth of blood vessels and successfully integrate the newly formed bone cells with the native bone. Trials on rabbits have been promising. A scaffold made of silk composite functionalised with copper-doped … Continue reading IIT Guwahati develops silk scaffold for bone regeneration

IIT Kanpur researchers find why babies need to move in the womb

IIT Kanpur researchers have found how permanent cartilage is formed in an embryo due to mechanical movement. The permanent cartilage gets lost and transient cartilage forms in its place in the absence of movement. In the developing embryos, the joints do not form at all if movement is restricted. Studies are on to find out if it … Continue reading IIT Kanpur researchers find why babies need to move in the womb

NCCS’ novel approach improves success rate of bone marrow transplantation

Researchers from Pune’s National Centre for Cell Science (NCCS) have found that co-culturing aged haematopoietic stem cells with young mesenchymal stromal cells will rejuvenate the stem cells and improve their functionality. When done prior to transplantation, the rejuvenation will help improve the engrafting efficiency of stem cells. This novel method will expand the pool of donors for bone … Continue reading NCCS’ novel approach improves success rate of bone marrow transplantation