Vaijayanti Kale from NCCS explains how micro-vesicles containing certain factors increase homing and engraftment potential of hematopoietic stem cells. These micro-vesicles also help in expanding hematopoietic stem cells before transplantation. The micro-vesicles are secreted by mesenchymal stem cells when treated with a nitric oxide donor.
Bone marrow transplantation
NCCS’ new approach makes bone marrow transplantation more successful
NCCS researchers have found a way to expand hematopoietic stem cells before transplantation and also improve the engraftment potential. Mesenchymal stem cells treated with a nitric oxide donor secreted micro-vesicles containing certain factors that increase the engraftment potential of hematopoietic stem cells. One of the reasons why the efficiency of bone marrow transplantation gets compromised is due to … Continue reading NCCS’ new approach makes bone marrow transplantation more successful
NCCS’ novel approach improves success rate of bone marrow transplantation
Researchers from Pune’s National Centre for Cell Science (NCCS) have found that co-culturing aged haematopoietic stem cells with young mesenchymal stromal cells will rejuvenate the stem cells and improve their functionality. When done prior to transplantation, the rejuvenation will help improve the engrafting efficiency of stem cells. This novel method will expand the pool of donors for bone … Continue reading NCCS’ novel approach improves success rate of bone marrow transplantation