NII unravels how diet restriction delays ageing, increases lifespan

A NII-led team has unravelled how C. elegans exposed to early-life, moderate stress in the form of dietary restriction are able to better handle chronic stress that comes with ageing and thereby increase longevity. The small stress also helps delaying certain age-onset diseases such as Huntington’s and Alzheimer’s. The role of dietary restriction in delaying … Continue reading NII unravels how diet restriction delays ageing, increases lifespan

TIFR researchers discover a novel function of serotonin

In a surprising discovery, TIFR researchers have found a novel function for serotonin — generation of new mitochondria in neurons, increased cellular respiration and ATP production. The team found that serotonin reduces reactive oxygen species, thus providing neuroprotection against cellular stress. In a surprising discovery, researchers at the Tata Institute of Fundamental Research (TIFR) Mumbai … Continue reading TIFR researchers discover a novel function of serotonin

JNCASR team fully restores long-term memory in mice with Alzheimer’s 

JNCASR researchers along with French counterparts have been able to fully restore neuron to neuron connections and long-term memory in mice with Alzheimer’s disease using a small molecule that activates two enzymes. The molecule attached to carbon nanospheres was able to breach the blood-brain barrier and reach the brain in sufficient concentration. Using a small … Continue reading JNCASR team fully restores long-term memory in mice with Alzheimer’s 

Podcast: Drug target to treat Parkinson’s, Alzheimer’s and cancer discovered

Researchers at the Institute of Life Sciences, Bhubaneswar have identified the novel mechanism by which misfolded proteins form aggregates and get degraded in the cells. They have discovered that downregulation of TRIM16 protein may help in treating cancers, while activation of the TRIM16 protein may have therapeutic benefits in the case of neurodegerative diseases such as … Continue reading Podcast: Drug target to treat Parkinson’s, Alzheimer’s and cancer discovered

Bhubaneswar team discovers a drug target for neurodegenerative diseases, cancer

Institute of Life Sciences researchers have discovered that downregulation of a protein drug target can help in the treatment of cancers, while activation can do the same for neurodegerative diseases such as Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis. They have identified the novel mechanism by which misfolded proteins form aggregates and get degraded in the cells. … Continue reading Bhubaneswar team discovers a drug target for neurodegenerative diseases, cancer

IISc team identifies a biomarker for early-stage Alzheimer’s

IISc researchers have ascertained that decrease in F-actin protein level results in early behavioural changes that would eventually lead to Alzheimer’s disease. F-actin thus behaves as an early biomarker of Alzheimer’s. Restoring the F-actin to normal levels resulted in Alzheimer mice behaving like healthy mice. IISc researchers have ascertained that decrease in F-actin protein level results in … Continue reading IISc team identifies a biomarker for early-stage Alzheimer’s

BHU researchers a step closer to preventing Alzheimer’s

Researchers from the Department of Biochemistry at the Institute of Medical Sciences, Banaras Hindu University (BHU) are a step closer to preventing Alzheimer’s disease. An effective antidote against amyloid beta peptide that causes Alzheimer’s disease and cerebral amyloid angiopathy has been found. A team of researchers led by Prof. Debabrata Dash has demonstrated for the … Continue reading BHU researchers a step closer to preventing Alzheimer’s

Thanks to air pollution, magnetic particles found in the brain

The effects of air pollution on human health has gone up by a few notches with the discovery of large number of rounded magnetite nanoparticles of about 18 nanometres in diameter (and maximum of 150 nm) in the frontal cortex tissue of the brain of 37 people. The people studied were 3-92 years old and … Continue reading Thanks to air pollution, magnetic particles found in the brain

Indian researchers show cancer drugs can stop the progression of Alzheimer’s, Parkinson’s

In a breakthrough, researchers from the University of Delhi found that the progression of Alzheimer’s and Parkinson’s diseases can be suppressed or stopped by downregulating the expression level of d-myc in Drosophila (fruit fly).  Since d-myc in an evolutionarily conserved human homolog of c-myc proto-oncogene, the findings in fruit fly may be applicable to humans … Continue reading Indian researchers show cancer drugs can stop the progression of Alzheimer’s, Parkinson’s