Kolkata researchers use novel compound to kill cancer cells

Twenty-five quinoline derivatives synthesised by IICB researchers and tested in the lab by IACS team show potent anticancer activity. The mode of action is the same for current drugs and the compounds tested. The difference is that topoisomerase 1-DNA complexes remain trapped for a longer time when the compounds are used and so have greater … Continue reading Kolkata researchers use novel compound to kill cancer cells

IIT Roorkee identify salivary protein biomarkers of breast, ovarian cancer metastasis

IIT Roorkee researchers have identified certain proteins found in saliva that can be used as potential biomarkers indicative of breast and ovarian cancer metastasis. The composition and expression of salivary gland-derived proteins are altered in people with breast and ovarian cancer. So studying the salivary proteins may offer an easy alternative for screening cancer patients. … Continue reading IIT Roorkee identify salivary protein biomarkers of breast, ovarian cancer metastasis

Podcast: How progesterone protects breast cancer patients unravelled

Dr. Amit Dutt of ACTREC-Tata Memorial Centre explains how progesterone administered prior to breast cancer surgery helps in reducing the chances of migration and invasion of cancer cells to other parts of the body. Immaterial of whether patients had progesterone receptor or not, the hormone is equally effective.

TMC team unravels protective mechanism of progesterone in breast cancer patients

Tata Memorial Centre researchers have uncovered the mechanism by which a single injection of progesterone administered prior to breast cancer surgery helps in reducing the chances of cancer cell spread (causing a relapse) whether patients have progesterone receptors or not. Since progesterone cannot be given to men and children, the results of the study can … Continue reading TMC team unravels protective mechanism of progesterone in breast cancer patients

Podcast: Drug loaded in nanovesicles improves cancer drug delivery

IISER Pune researchers have increased the uptake of poorly water-soluble anticancer drug by loading it in nanovesicles that self-assemble. The nanovesicles can be loaded with both hydrophilic and hydrophobic drugs. The encapsulated drug produced 94% silencing of the target AURKA leading to 25% inhibition of RalA. As a result, there was 38% inhibition of anchorage independent growth … Continue reading Podcast: Drug loaded in nanovesicles improves cancer drug delivery

IISER Pune team uses nanovesicles to improve cancer drug delivery

IISER Pune researchers have increased the uptake of poorly water-soluble anticancer drug by loading it in nanovesicles that self-assemble. The nanovesicles can be loaded with both hydrophilic and hydrophobic drugs. The encapsulated drug produced 94% silencing of the target AURKA leading to 25% inhibition of RalA. As a result, there was 38% inhibition of anchorage independent … Continue reading IISER Pune team uses nanovesicles to improve cancer drug delivery

IIT Gandhinagar team takes initial step to treat breast, prostate cancer

IIT Gandhinagar researchers have successfully produced large quantity of a biologically active protein involved in DNA damage response pathway in breast and prostate cancer cells. A handful of small molecules synthesised by them was able to achieve up to 75% inhibition of the protein thus preventing it from repairing DNA damage in cancer cells caused by radiation or … Continue reading IIT Gandhinagar team takes initial step to treat breast, prostate cancer

IISc researchers overthrow cancer metastasis dogma

IISc researchers have uncovered a novel mechanism by which cancer cells in circulation stay alive. They found the protein kinase AMPK gets activated when cancer cells detach from extracellular matrix, and, in turn, inhibits another protein kinase Akt. This finding overturns the two-decade dogma that Akt is vital for the survival of circulating cancer cells. The … Continue reading IISc researchers overthrow cancer metastasis dogma

IISER Pune researchers study the early stages of transformation into cancerous cells

Researchers at IISER Pune have found a particular protein (DNA-dependent protein kinase, DNA-PK), which normally repairs any damage to cell DNA, playing a central role in the transformation of normal cells into cancerous cells. The activated DNA-PK disrupts the structure and function of the Golgi, trafficking and polarity of epithelial cells, leading to the transformation. Researchers from … Continue reading IISER Pune researchers study the early stages of transformation into cancerous cells

IIT teams use plant extract, heat to kill skin cancer cells

On being irradiated with near infrared light the dye gets heated up and facilitates the release of the extract from polymer membrane. After 4-5 minutes of irradiation about 80% of cancer cells were killed by both enhanced ROS generation inside cancer cells and by photothermal ablation. Nanoparticle formulation of a chlorophyll-rich biomolecular extract of an … Continue reading IIT teams use plant extract, heat to kill skin cancer cells