IGIB researchers have discovered a pathway that regulates hepcidin hormone production. The hepcidin hormone is a central regulator of iron in the body, and its dysregulation can lead to anaemia or excess iron accumulation in liver and heart, leading to multi-organ failure. The researchers identified a target pathway using a different approach and found a … Continue reading IGIB team finds a new target to reverse iron overload disease
Rare genetic disease
IGIB team partially reverses a rare disease
Researchers at IGIB have demonstrated that zebrafish can be used an animal model to study Rubinstein Taybi Syndrome (RSTS) in humans. They were able to partially reverse the disorder using a tiny portion of the Ep300a protein, and also by using two small molecules. Researchers at Delhi’s Institute of Genomics & Integrative Biology (CSIR-IGIB) have … Continue reading IGIB team partially reverses a rare disease
Indian researchers turn to zebrafish to study microvillus inclusion disease
Indian researchers have finally found an ideal animal model to study microvillus inclusion disease (MVID) that may affect children born out of consanguineous marriages and to screen potential drugs to treat the disease. Currently, children with MVID disease have no treatment and mostly die premature as babies as they suffer from malabsorption of nutrients and … Continue reading Indian researchers turn to zebrafish to study microvillus inclusion disease
Zebrafish provide insights into a rare human disease
Scientists from the Delhi-based CSIR-Institute of Genomics and Integrative Biology are a step closer to bringing hope to children born with a rare disorder — CHARGE syndrome — if the results seen in zebrafish are reproducible in humans. The results of a study were published on July 13 in the journal Human Molecular Genetics. About 1 in … Continue reading Zebrafish provide insights into a rare human disease
Screening for rare genetic disorders becomes easier
Fast and accurate diagnosis of disease-causing mitochondrial genetic mutations is now possible thanks to automation of the entire process of data analysis and interpretation by a team of researchers at the Delhi-based CSIR Institute of Genomics and Integrative Biology. The comprehensive pipeline developed by a team led by Dr. Sridhar Sivasubbu and Dr. Vinod Scaria of … Continue reading Screening for rare genetic disorders becomes easier
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