Cheap, filter-based kits developed for TB diagnosis, drug-resistance testing

Three cheap, filter-based kits developed by a multi-institutional team and an industry partner improves the sensitivity of LED fluorescence microscopy by 5%, enable transport of sputum samples at ambient conditions without bio-safe containers and TB drug-resistance testing using molecular methods. To address the TB diagnostic challenges, a multi-institutional team has developed three cost-effective kits that … Continue reading Cheap, filter-based kits developed for TB diagnosis, drug-resistance testing

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Podcast: FDA-approved asthma drug effectively treats TB

Archita Mishra and other researchers from IISc found that a FDA-approved asthma drug can be used for treating TB. Laboratory studies found the drug to be more effective in curtailing the growth of TB bacteria when used alone and in combination with anti-TB drugs — rifampicin and isoniazid. The drug was also able to prevent the … Continue reading Podcast: FDA-approved asthma drug effectively treats TB

IISc researchers find asthma drug effective in treating TB

Researchers at IISc used a FDA-approved asthma drug to treat TB. Laboratory studies found the drug to be more effective in curtailing the growth of TB bacteria when used alone and in combination with anti-TB drugs — rifampicin and isoniazid. The drug was also able to prevent the bacteria from causing inflammation thereby proving to be … Continue reading IISc researchers find asthma drug effective in treating TB

A glimmer of hope as India’s war on TB gets more funding

There is a glimmer of hope with India registering a slight drop in the number of new tuberculosis cases and TB deaths in 2016 compared with 2015. From an estimated 2.84 million new cases in 2015, the number dropped marginally to 2.79 million in 2016, according to the World Health Organisation’s Global tuberculosis report, 2017. … Continue reading A glimmer of hope as India’s war on TB gets more funding

A looming threat of tuberculosis in children

The RNTCP guidelines on contact screening are heeded mostly in the breach. About 5,500 of over 76,000 children tested in nine Indian cities have been diagnosed with tuberculosis, 9% of them with multidrug-resistant TB (MDR-TB), highlighting the silent spread of the disease. Though the actual prevalence of MDR-TB among children in India is not known, … Continue reading A looming threat of tuberculosis in children

Cheaper TB diagnostic test developed in India enters final validation stage

A cheaper, locally developed molecular diagnostic test, Truenat MTB, for drug-sensitive and rifampicin-resistant TB is entering the final leg of performance validation and operational feasibility testing by the Indian Council of Medical Research (ICMR). Truenat is developed by the Goa-based Molbio Diagnostics. The company was provided with technical assistance and resources by the Foundation for Innovative New Diagnostics … Continue reading Cheaper TB diagnostic test developed in India enters final validation stage

Pilot testing of bedaquiline drug on TB patients to start soon

A pilot programme to test the toxicity, particularly cardio-toxicity, of bedaquiline drug (used for combating multidrug-drug resistant TB) in the Indian population, assess its ability to achieve culture conversion and check the operational feasibility of using the drug to treat MDR-TB patients would start in India by the end of this month or on World … Continue reading Pilot testing of bedaquiline drug on TB patients to start soon

TB: India study confirms Xpert diagnostic test’s superiority

For the first time in India, the superiority of Xpert MTB/RIF over smear microscopy for bacteriological confirmation of pulmonary TB and in diagnosing MDR-TB (Multi Drug Resistant-TB) patients before initiating any treatment has been proved in a large-scale study undertaken in 2012-2013. Encouraging results The latest study, the largest in the world, found that using … Continue reading TB: India study confirms Xpert diagnostic test’s superiority

Is the new TB drug already being misused?

Bedaquiline was the first TB drug to be discovered in more than 40 years, and the first one specifically for multi-drug resistant TB (MDR-TB). MDR-TB arises when the M. tuberculosis bacteria become resistant to two commonly used first-line TB drugs — isonazid and rifampicin. But less than six months after FDA approved the drug under … Continue reading Is the new TB drug already being misused?

WHO-approved TB test, now at a subsidised price

Published in The Hindu on March 28, 2013 Providing accurate diagnosis for TB and thereby enabling earlier initiation of treatment has got a big boost. Currently, around 30 private laboratories across the country have come together to provide the WHO-approved GeneXpert MTB/RIF molecular test to diagnose active TB at a subsidised ceiling price of Rs.1,700 … Continue reading WHO-approved TB test, now at a subsidised price