Novel coronavirus-specific nutralising antibodies last at least for six months

The researchers found that neutralizing antibodies were over 70% even at the end of six months. While IgG showed an initial contraction but stabilised at relatively high levels over the six months observation period, IgM became undetectable in most patients three months after disease onset. Novel coronavirus-specific antibodies — IgM and IgG antibodies — were … Continue reading Novel coronavirus-specific nutralising antibodies last at least for six months

SARS-CoV-2-specific T cell immunity prevents recurrent severe COVID-19 disease

The immune system elicits robust, broad and highly functional memory T cell responses once a person is infected with novel coronavirus. T cells were found even in the absence of detectable antibodies specific to SARS-CoV-2. This indicates a previously unanticipated degree of population-level immunity against COVID-19. Natural exposure or infection with the novel coronavirus may … Continue reading SARS-CoV-2-specific T cell immunity prevents recurrent severe COVID-19 disease

Interim results of phase-1-2 trials find inactivated coronavirus vaccine is safe

Interim results of Phase-1 and Phase-2 trials of an inactivated SARS-CoV-2 vaccine carried out in China show that the vaccine is well tolerated, safe, and produced neutralizing antibodies at 14 days after booster vaccination. Over 90% receiving the vaccine developed neutralizing antibodies. Interim results of Phase-1 and Phase-2 trials of an inactivated SARS-CoV-2 vaccine carried out … Continue reading Interim results of phase-1-2 trials find inactivated coronavirus vaccine is safe

One more study shows people unexposed to novel coronavirus have pre-existing immunity

One more study has shown that pre-existing T cell memory against four common cold coronaviruses can cross-recognise novel coronavirus (SARS-CoV-2) even when the person has never been infected with SARS-CoV-2 before. One more study has shown that pre-existing T cell memory against four common cold coronaviruses can cross-recognise novel coronavirus (SARS-CoV-2) even when the person … Continue reading One more study shows people unexposed to novel coronavirus have pre-existing immunity

Study finds evidence of  vertical transmission of coronavirus across the placenta

While about half-a-dozen studies published have already suggested vertical transmission of novel coronavirus from the mother to child, a study now published confirms the direction of transmission as vertical and also identifies the route of transmission as transplacental. Transmission of novel coronavirus through droplets and contact with contaminated surfaces seem to be the major routes … Continue reading Study finds evidence of  vertical transmission of coronavirus across the placenta

Some people unexposed to novel coronavirus have pre-existing immunity

At least five studies found people unexposed to novel coronavirus exhibiting T cell immune responses specific to SARS-CoV-2. This might be arising from memory T cells derived from previous exposure to ‘common cold’ coronaviruses. This may have implications in infection prevention/disease progression and vaccine development. At least five studies (one published in journal Cell, and … Continue reading Some people unexposed to novel coronavirus have pre-existing immunity

Antibodies from convalescent plasma protects against COVID-19

The researchers found passive transfer of neutralising antibodies isolated from convalescent plasma into Syrian hamsters protect the animals against the disease when exposed to the virus and also protects hamsters against heavy viral exposure. A team of scientists led by Dennis R. Burton from the Scripps Research Institute has discovered neutralising antibodies present in the … Continue reading Antibodies from convalescent plasma protects against COVID-19

Antibodies against coronavirus start to decrease in 2-3 months, study finds

The study found IgG levels and neutralizing antibodies started to decrease within two-three months after infection with novel coronavirus. The reduction was more (40%) in the case asymptomatic individuals than symptomatic individuals (nearly 13%). A few countries, including UK, were toying with the idea of issuing some form of a certificate to people who have … Continue reading Antibodies against coronavirus start to decrease in 2-3 months, study finds

COVID-19: Younger patients develop less neutralising antibodies

About 30% of patients with mild symptoms failed to develop high amounts of neutralising antibodies even after recovering from COVID-19 disease. If natural infection with novel coronavirus does not elicit strong immune response, how much will vaccines be able to achieve. Analysis of blood samples from 175 patients with mild COVID-19 disease who were discharged … Continue reading COVID-19: Younger patients develop less neutralising antibodies

Study finds possible vertical transmission of novel coronavirus

A newborn was found to have antibodies against novel coronavirus just two hours after  (caesarean) delivery. The mother tested positive three weeks before delivery. Since it takes three-seven days for antibodies to the virus to start appearing, the foetus is likely to have been exposed to the virus. A possible case of transmission of novel … Continue reading Study finds possible vertical transmission of novel coronavirus