Novel way found to kill dormant TB bacteria in stem cells

Delhi-based researchers have found that TB bacteria promote rapid synthesis of lipids inside mesenchymal stem cells and hide within the lipid droplets so created. They found that TB bacteria hijack the cellular mechanism to stop the stem cells from replicating and turn themselves dormant. They found a way to rid the stem cells of bacteria and … Continue reading Novel way found to kill dormant TB bacteria in stem cells

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Cheap, filter-based kits developed for TB diagnosis, drug-resistance testing

Three cheap, filter-based kits developed by a multi-institutional team and an industry partner improves the sensitivity of LED fluorescence microscopy by 5%, enable transport of sputum samples at ambient conditions without bio-safe containers and TB drug-resistance testing using molecular methods. To address the TB diagnostic challenges, a multi-institutional team has developed three cost-effective kits that … Continue reading Cheap, filter-based kits developed for TB diagnosis, drug-resistance testing

IIITD-AIIMS team’s model can predict shock 12 hours in advance

A team led by IIITD-AIIMS researchers has developed a machine-learning algorithm to detect and predict shock using a single photo captured through thermal imaging. It has the ability to predict shock with 69% accuracy 12 hours before it can be clinically recognised by doctors using the current gold standard. The researchers plan to deploy it … Continue reading IIITD-AIIMS team’s model can predict shock 12 hours in advance

Podcast: Diagnosing krait snake venom

Anjali Anand from Translational Health Science and Technology Institute (THSTI), Faridabad explains how researchers from THSTI, AIIMS and IIT Indore found the aptamer originally developed against alpha toxin of Bungarus multicinctus krait snake found in China and Taiwan can be used for reliable detection of B. caeruleus krait species found in the Indian subcontinent. The researchers have developed inhouse … Continue reading Podcast: Diagnosing krait snake venom

Indian researchers take first step to diagnose krait snake venom

Researchers from THSTI, AIIMS and IIT Indore have found that the aptamer originally developed against alpha toxin of Bungarus multicinctus krait snake found in China and Taiwan can be used for reliable detection of B. caeruleus krait species found in the Indian subcontinent. The truncated aptamer shows better affinity, sensitivity and binding to the target than … Continue reading Indian researchers take first step to diagnose krait snake venom

AIIMS-led team develops sensitive diagnostic tests for TB

Researchers have developed highly sensitive and specific diagnostic tests for pulmonary TB and pleural TB. The diagnostic tests make use of a DNA aptamer that shows high binding affinity to a TB antigen. Sputum samples were used for diagnosing pulmonary TB while pleural fluid was used for diagnosing pleural TB. A highly sensitive diagnostic test for … Continue reading AIIMS-led team develops sensitive diagnostic tests for TB

Podcast: Blocking the entry of TB bacteria into host cells

Scientists from AIIMS, THSTI and IIT Indore have successfully been able to inhibit the entry of TB bacteria into host cells by using aptamer-based inhibitor that binds to the HupB protein found on TB bacteria cell surface.  The researchers are now trying to deliver the aptamer into the TB bacterial cell to inhibit the DNA-binding function … Continue reading Podcast: Blocking the entry of TB bacteria into host cells

Small DNA-based inhibitor blocks entry of TB bacteria into host cells

A team of researchers from three institutions in India has used aptamer-based inhibitor that binds to the HupB protein found on TB bacteria cell surface to significantly inhibit the entry of the bacteria into host cells. The researchers are now trying to deliver the aptamer into TB bacterial cell. If successful, it will make the … Continue reading Small DNA-based inhibitor blocks entry of TB bacteria into host cells

AIIMS-led team develops highly sensitive, portable test for TB meningitis

A team led by Jaya Sivaswami Tyagi from AIIMS in collaboration with THSTI has developed a diagnostic test for TB meningitis with nearly 100% sensitivity and about 91% specificity. The rapid, point-of-care diagnostic test for TB meningitis, which uses the DNA aptamer, has already been adapted to a sensor format and is being evaluated on clinical samples. … Continue reading AIIMS-led team develops highly sensitive, portable test for TB meningitis

Delhi researchers use AI to diagnose asthma, identify subtypes

Studying the total NMR spectra of metabolites present in exhaled breath of children with asthma, IGIB and AIIMS researchers have been able to improve the diagnosis of asthma and identify three asthma subtypes using artificial intelligence. Knowing the subtypes will help in providing better treatment strategies. The algorithm has 80% sensitivity and 75% specificity in … Continue reading Delhi researchers use AI to diagnose asthma, identify subtypes