IIT Kanpur team identifies a novel target to treat prostate cancer

Researchers at IIT Kanpur have discovered that a particular gene (DLX1), which plays an important role in the development of jaws, skeleton, and interneurons in the brain, has an important role to play in the growth and development of prostate cancer. Researchers at the Indian Institute of Technology (IIT) Kanpur have discovered that a particular … Continue reading IIT Kanpur team identifies a novel target to treat prostate cancer

A safer alternative approach to treat aggressive prostate cancer found

A multi-institutional team led by IIT Kanpur has found the mechanism responsible for the aggressive return of prostate cancer in treated patients. They also found that treating prostate cancer cells showing elevated SPINK1 protein with a drug against Casein Kinase 1 resulted in reduced cancer cell growth as well as aggressiveness. A study shows why … Continue reading A safer alternative approach to treat aggressive prostate cancer found

IIT Kanpur identifies novel molecule for inflammatory disorders

IIT Kanpur researchers have identified and characterised a novel small protein molecule that can effectively control inflammation leading to better treatment outcomes than the ones undergoing clinical trials. Researchers at the Indian Institute of Technology (IIT) Kanpur have identified and characterised a novel small protein molecule that can effectively control inflammation leading to better treatment … Continue reading IIT Kanpur identifies novel molecule for inflammatory disorders

IIT Kanpur team unravels molecular mechanism of a prostate cancer subtype

IIT Kanpur-led team discovers the molecular mechanism by which a protein (EZH2) is produced in excess leading to a reduction in the levels of two microRNAs. This causes an oncogene (SPINK1) to get overexpressed in the SPINK1-positive prostate cancer subtype.  Synthetic microRNAs and epigenetic drugs that increase the microRNA levels reduce tumour growth and metastasis. … Continue reading IIT Kanpur team unravels molecular mechanism of a prostate cancer subtype

IIT researchers 3D bioprint load-bearing bones

Researchers from IIT Delhi and IIT Kanpur have used a different approach to mimic the development biology pathway by which adult load-bearing bones are formed. The researchers made the stem cells to first differentiate into cartilage, and the cartilage was then converted into bones. The bones tissue engineered showed more similarity to limb skeleton development … Continue reading IIT researchers 3D bioprint load-bearing bones

Pollution reduces day time temperature during Indian summer monsoon

Increased aerosol loading in the atmosphere due to pollution has led to changes in the number, shape and characteristics of the rain-bearing clouds. The increased cloud reflectance has led to 1 degree C drop in day time temperature during Indian summer monsoon. At the same time, night time temperature is increasing thus shrinking the diurnal … Continue reading Pollution reduces day time temperature during Indian summer monsoon

NBRC-led team deciphers how Zika virus causes microcephaly

The NBRC-led team of researchers has identified the molecular and cellular mechanisms by which Zika virus causes microcephaly. The envelop protein of the virus was responsible for arresting the proliferation of human foetal neural stem cells and also killing the cells that were becoming neuron-like. The combined effect reduces the pool of foetal brain cells leading to … Continue reading NBRC-led team deciphers how Zika virus causes microcephaly

IIT Kanpur researchers find why babies need to move in the womb

IIT Kanpur researchers have found how permanent cartilage is formed in an embryo due to mechanical movement. The permanent cartilage gets lost and transient cartilage forms in its place in the absence of movement. In the developing embryos, the joints do not form at all if movement is restricted. Studies are on to find out if it … Continue reading IIT Kanpur researchers find why babies need to move in the womb

IIT Kanpur team finds possible cause of neurodevelopmental disorders

BMP signalling was previously known to play an important role in the early development of the brain. Now, IIT Kanpur researchers have found that BMP signalling plays an important role in cerebral cortex development by regulating the migration of new born cortical neurons and the establishment of polarity in the upper layer of cerebral cortex. … Continue reading IIT Kanpur team finds possible cause of neurodevelopmental disorders

Diagnosing early-stage cervical cancer using artificial intelligence

Using an artificial intelligence-based algorithm that uses scattered light data from tissues, researchers from IISER Kolkata and IIT Kanpur have been able to differentiate normal and precancerous tissue, and even identify the different stages of progression of the disease within a few minutes and with great accuracy. In vivo studies are now being carried out. … Continue reading Diagnosing early-stage cervical cancer using artificial intelligence