A molecule identified by IIT Roorkee researchers exhibits broadspectrum bactericidal activity against multidrug-resistant bacteria. The molecule was found to be effective against persister bacteria as well. Screening a small-molecule library of about 11,000 compounds, researchers at the Indian Institute of Technology (IIT) Roorkee identified a potent molecule that exhibits broadspectrum bactericidal activity against multidrug-resistant bacteria … Continue reading IIT Roorkee’s novel molecule effective against multi-drug resistant bacteria
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IIT Roorkee identify salivary protein biomarkers of breast, ovarian cancer metastasis
IIT Roorkee researchers have identified certain proteins found in saliva that can be used as potential biomarkers indicative of breast and ovarian cancer metastasis. The composition and expression of salivary gland-derived proteins are altered in people with breast and ovarian cancer. So studying the salivary proteins may offer an easy alternative for screening cancer patients. … Continue reading IIT Roorkee identify salivary protein biomarkers of breast, ovarian cancer metastasis
Podcast: Treating chikungunya using tamarind seed protein
Shailly Tomar of IIT Roorkee explains how her team found a protein in tamarind seeds that binds to NAG sugar molecule on chikungunya virus and reduces infectivity by 64% and RNA levels inside infected cells by nearly 45%.
IIT Roorkee team uses tamarind seed protein to treat chikungunya
IIT Roorkee researchers have found that a protein (TCLL) in tamarind seeds binds to NAG sugar molecule on chikungunya virus and reduces infectivity by 64% and RNA levels inside infected cells by nearly 45%. The TCLL protein can bind to glycan found on nearly 30 members of the alphavirus genus. So the finding has huge implications. Researchers … Continue reading IIT Roorkee team uses tamarind seed protein to treat chikungunya
Podcast – Finding new drug target for Acinetobacter baumannii bacteria
IIT Roorkee researchers have identified the RNA protein Hfq as a potential drug target. Once the Hfq gene is removed, the Acinetobacter baumannii bacteria become less virulent, more susceptible to environmental stress, and survival under desiccation is compromised. Targeting the virulence of the bacteria opens up a new opportunity to develop more effective drugs.
IIT Roorkee finds new drug target for antibiotic resistant bacteria Acinetobacter baumannii
IIT Roorkee researchers have identified the RNA protein Hfq as a potential drug target. Once the Hfq gene is removed, the Acinetobacter baumannii bacteria become less virulent, more susceptible to environmental stress, and survival under desiccation is compromised. Targeting the virulence of the bacteria opens up a new opportunity to develop more effective drugs. Researchers … Continue reading IIT Roorkee finds new drug target for antibiotic resistant bacteria Acinetobacter baumannii
IIT Roorkee finds a potent antiviral molecule to treat chikungunya
Of the two small molecules tested, IIT Roorkee researchers have found one of them has good antiviral activity against chikungunya virus. The small molecule was able to achieve almost 99% reduction in the virus when 5 microMolar of the molecule was used. The molecule is highly specific to chikungunya virus. A team of researchers at the Indian … Continue reading IIT Roorkee finds a potent antiviral molecule to treat chikungunya
IIT Roorkee’s novel molecule reverses antibiotic resistance
The small molecule used by Prof. Ranjana Pathania's team at IIT Roorkee inhibits the proton gradient that drives the efflux pump leading to an effective build-up of antibiotic inside multidrug-resistant bacteria Acinetobacter baumannii and subsequent bacterial death. The small molecule can potentially inhibit a wide variety of proton-driven efflux pumps in many multidrug-resistant pathogens. Using a small molecule screened from … Continue reading IIT Roorkee’s novel molecule reverses antibiotic resistance
IIT Roorkee team repurposes a drug for chikungunya
The Piperazine drug used for treating worm infections and HIV has been able to inhibit the replication of chikungunya virus by nearly 98%. A drug to treat chikungunya virus infection is in the offing, and in vitro studies carried out by a team of researchers from the Indian Institute of Technology (IIT) Roorkee show promise. Currently, there … Continue reading IIT Roorkee team repurposes a drug for chikungunya
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