IACS fabricates hydrogels with tunable bactericidal activities

IACS researchers have fabricated a cytidine-based hydrogel that self-assembles in the presence of silver acetate and boronic acid and exhibits antibacterial activity against Gram-negative bacteria. The hydrogel can be used for drug delivery applications by using external stimuli such as mechanical stress or by changing the pH. Researchers at the Indian Association for the Cultivation … Continue reading IACS fabricates hydrogels with tunable bactericidal activities

Kolkata researchers use novel compound to kill cancer cells

Twenty-five quinoline derivatives synthesised by IICB researchers and tested in the lab by IACS team show potent anticancer activity. The mode of action is the same for current drugs and the compounds tested. The difference is that topoisomerase 1-DNA complexes remain trapped for a longer time when the compounds are used and so have greater … Continue reading Kolkata researchers use novel compound to kill cancer cells

IACS team designs logic devices for DNA-based computation

IACS scientists have designed DNA-based logic devices that would find application in DNA-based computation. The reusable YES and INHIBIT logic systems has been built by using a fluorescent small molecule that binds to both G-quadruplex and nucleases. They have also designed combinatorial logic systems (INHIBIT−INHIBIT and NOR−OR) by using different combinations of four nucleases as inputs. … Continue reading IACS team designs logic devices for DNA-based computation

IACS researchers use a novel compound to kill cancer cells

IACS researchers have synthesised a novel porphyrin compound that shows potent anticancer activity. The porphyrin compound selectively targets and binds to cellular topoisomerase 1 enzyme, which is essential for maintenance of DNA architecture in the cells, found in cancer cells and causes cell death. Researchers at Kolkata’s Indian Association for the Cultivation of Science (IACS) … Continue reading IACS researchers use a novel compound to kill cancer cells

IACS researchers use a novel approach to cancer drug discovery

Four-stranded DNA structures known as G-quadruplexes, which  are present in human genome, can control the activities of cancer-causing genes and hence have emerged as anticancer drug targets. Scientists at the Indian Association for the Cultivation of Science, Jadavpur, Kolkata have used a novel approach to drug discovery by attaching or linking a DNA sequence of … Continue reading IACS researchers use a novel approach to cancer drug discovery