IGIB unravels a new mechanism TB bacteria use to subvert host defence

IGIB researchers have found that besides degradative pathways, TB bacteria actively manipulate another organelle — lipid droplets in macrophages. When lipid droplets are infected with TB bacteria, the composition of 86 proteins gets altered. Based on increased abundance of certain proteins, the team found two pathways have a link with lipid metabolism. It is well … Continue reading IGIB unravels a new mechanism TB bacteria use to subvert host defence

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IIITD-AIIMS team’s model can predict shock 12 hours in advance

A team led by IIITD-AIIMS researchers has developed a machine-learning algorithm to detect and predict shock using a single photo captured through thermal imaging. It has the ability to predict shock with 69% accuracy 12 hours before it can be clinically recognised by doctors using the current gold standard. The researchers plan to deploy it … Continue reading IIITD-AIIMS team’s model can predict shock 12 hours in advance

Podcast: New target to reverse iron overload disease

IGIB researchers have discovered a pathway that regulates hepcidin hormone production. The hepcidin hormone is a central regulator of iron in the body and its dysregulation can lead to anaemia or excess iron accumulation in liver and heart, leading to multi-organ failure. The researchers identified the target pathway using a different approach and found a … Continue reading Podcast: New target to reverse iron overload disease

IGIB team finds a new target to reverse iron overload disease

IGIB researchers have discovered a pathway that regulates hepcidin hormone production. The hepcidin hormone is a central regulator of iron in the body, and its dysregulation can lead to anaemia or excess iron accumulation in liver and heart, leading to multi-organ failure. The researchers identified a target pathway using a different approach and found a … Continue reading IGIB team finds a new target to reverse iron overload disease

Podcast: Finding a promising target to reduce TB’s tissue-damaging effects

Institute of Genomic and Integrative Biology (CSIR-IGIB), Delhi, researchers have for the first time discovered that necrosis in granulomas result in the development of lipid-rich foamy macrophages, thus overthrowing the general belief that TB bacteria make the host cells accumulate lipids. They also report for the first time that foamy macrophages show more inflammatory response than … Continue reading Podcast: Finding a promising target to reduce TB’s tissue-damaging effects

IGIB shows how fat cells protect TB bacteria from oxidative stress

IGIB researchers found that genes responsible for iron intake were less expressed in TB bacteria found in fat cells. The decreased expression provides protection to TB bacteria from iron-mediated oxidative stress. Different regions of a tissue have different levels of fat and iron, and TB bacteria have the ability to adapt to each condition, thus making … Continue reading IGIB shows how fat cells protect TB bacteria from oxidative stress

IGIB team partially reverses a rare disease

Researchers at IGIB have demonstrated that zebrafish can be used an animal model to study Rubinstein Taybi Syndrome (RSTS) in humans. They were able to partially reverse the disorder using a tiny portion of the Ep300a protein, and also by using two small molecules. Researchers at Delhi’s Institute of Genomics & Integrative Biology (CSIR-IGIB) have … Continue reading IGIB team partially reverses a rare disease

IGIB discovers a protein regulating melanoma growth, pigmentation

IGIB researchers have for the first time identified a calcium sensor protein (STIM1) that independently regulates both skin cancer and pigmentation. Since different parts of the STIM1 protein activate two independent signalling pathways that control melanoma growth and pigmentation, drug can be developed to target specific sites in the STIM1 protein to control tumour growth or regulate … Continue reading IGIB discovers a protein regulating melanoma growth, pigmentation

Delhi researchers use AI to diagnose asthma, identify subtypes

Studying the total NMR spectra of metabolites present in exhaled breath of children with asthma, IGIB and AIIMS researchers have been able to improve the diagnosis of asthma and identify three asthma subtypes using artificial intelligence. Knowing the subtypes will help in providing better treatment strategies. The algorithm has 80% sensitivity and 75% specificity in … Continue reading Delhi researchers use AI to diagnose asthma, identify subtypes

IGIB researchers reverse cancer drug resistance

Small molecules used along with anticancer drug makes cancer cells sensitive to the drug. Resistance to anticancer drugs is a major problem in oncology affecting a large number of cancer patients. Now, researchers at the CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi have found a way to make cancer cells that are resistant to two commonly used anticancer … Continue reading IGIB researchers reverse cancer drug resistance