IIT Guwahati’s bone graft aids extensive bone formation

IIT Guwahati’s scaffold made of silk-bone cement composite doped with silicon and zinc metal ions has been found to extensively regenerate new bone tissue and blood vessels in rabbits in three months. At the end of three months, silk fibre gets degraded, bone cement gets absorbed, while silicon and zinc get leached out. The team is now … Continue reading IIT Guwahati’s bone graft aids extensive bone formation

Podcast: Developing bioactive wound dressing, skin graft

IIT Guwahati researchers have developed bioactive wound dressings and bio-artificial skin by using silkworm silk fibroin as matrix and coating it with recombinant spider silk proteins. The recombinant spider silk reduced bacterial population by nearly four-fold and showed good anti-biofilm properties and recruited cells to the site of wound. The skin graft was bilayered (demis and epidermis) … Continue reading Podcast: Developing bioactive wound dressing, skin graft

IIT Guwahati use silk to develop bioactive wound dressing, skin graft

IIT Guwahati researchers have developed bioactive wound dressings and bio-artificial skin by using silkworm silk fibroin as matrix and coating it with recombinant spider silk proteins. The recombinant spider silk reduced bacterial population by nearly four-fold and showed good anti-biofilm properties and recruited cells to the site of wound. The skin graft was bilayered (demis and epidermis) … Continue reading IIT Guwahati use silk to develop bioactive wound dressing, skin graft

IIT Guwahati develops silk scaffold for bone regeneration

IIT Guwahati researchers have developed a scaffold made of silk composite functionalised with copper-doped bioactive glass. The scaffold facilitates faster and better bone regeneration, facilitates growth of blood vessels and successfully integrate the newly formed bone cells with the native bone. Trials on rabbits have been promising. A scaffold made of silk composite functionalised with copper-doped … Continue reading IIT Guwahati develops silk scaffold for bone regeneration

IIT Guwahati team fabricates spinal disc using silk

Researchers at IIT Guwahati have fabricated a silk-based spinal disc construct that mimics human intervertebral disc both in form and function. The construct allows annulus fibrosus cells or AF-like differentiated cells to grow and proliferate and deposit normal extracellular matrix. The construct was found to be biocompatible when implanted in mice. Using mulberry silk, researchers … Continue reading IIT Guwahati team fabricates spinal disc using silk

IIT Guwahati researchers create bioartificial liver using silk

IIT Guwahati researchers have created a bioartificial liver model grown within a 3D silk scaffold. The scaffold made by mixing mulberry and non-mulberry silk fibroins showed enhanced liver-specific functions. When implanted in animals, the scaffold was found to be biocompatible. The researchers are now validating the scaffold with primary human liver cells and human stem cell-derived liver … Continue reading IIT Guwahati researchers create bioartificial liver using silk

IIT Guwahati team creates an implantable ‘pancreas’ to treat Type 1 diabetes

The beta cells in the scaffold were able to produce adequate amount of insulin in response to different glucose levels within a few seconds. Researchers at the Indian Institute of Technology (IIT) Guwahati have successfully created an implantable bioartificial pancreas model grown within a 3D silk scaffold. The “pancreas”, which encapsulates the insulin-producing beta cells, … Continue reading IIT Guwahati team creates an implantable ‘pancreas’ to treat Type 1 diabetes

IIT Guwahati team develops silk patch to repair damaged heart tissue

Unlike current scaffolds, the 3D patch has high cell density, a foremost requirement for heart tissue. Scientists at the Indian Institute of Technology (IIT) Guwahati have fabricated a 3D cardiac tissue patch using silk protein membranes seeded with heart muscle cells. The patch can potentially be used for regenerating damaged heart tissue. “The 3D patch that … Continue reading IIT Guwahati team develops silk patch to repair damaged heart tissue