Podcast: New diagnostic tests for TB
Tarun Sharma explains how the team developed highly sensitive and specific diagnostic tests for pulmonary TB and pleural TB. The diagnostic tests make use of a DNA aptamer that shows high…
Category: Tuberculosis (TB)
AIIMS-led team develops sensitive diagnostic tests for TB
Researchers have developed highly sensitive and specific diagnostic tests for pulmonary TB and pleural TB. The diagnostic tests make use of a DNA aptamer that shows high binding affinity to a…
‘Unethical to withhold bedaquiline treatment while waiting for Phase III results’
In a Phase IIb trail, bedaquiline drug for MDR-TB treatment was found to be cardiotoxic and hepatotoxic, and it also caused more deaths. Review of evidence in 2015 showed a…
Podcast: New approaches to kill TB bacteria
Amit Singh from IISc explains how a protein (WhiB4) that condenses the DNA of TB-causing bacteria in response to oxidative stress was identified. The team found that artificially elevating the…
IISc team finds new approaches to kill TB bacteria
IISc researchers have for the first time identified a protein (WhiB4) that condenses the DNA of TB-causing bacteria in response to oxidative stress. They found that artificially elevating the levels of WhiB4…
Podcast: Ten-year journey to develop a diagnostic test for TB meningitis
A team lead by Jaya Sivaswami Tyagi from AIIMS in collaboration with THSTI has developed a diagnostic test for TB meningitis with nearly 100% sensitivity and about 91% specificity. The rapid, point-of-care…
AIIMS-led team develops highly sensitive, portable test for TB meningitis
A team led by Jaya Sivaswami Tyagi from AIIMS in collaboration with THSTI has developed a diagnostic test for TB meningitis with nearly 100% sensitivity and about 91% specificity. The rapid, point-of-care…
NCL-led team improves stability, bioavailability of FDC drug for TB
By turning to crystal engineering, the NCL-led team of researchers has improved the physical stability and bioavailability of a fixed-dose combination (FDC) drug containing four first-line anti-TB medicines. Cocrystal of isoniazid…
