Pretomanid: XDR-TB may soon become easily treatable
Though the total number of people with XDR-TB and treatment intolerant or non-responsive MDR-TB who will require the new anti-TB drug Pretomanid may not be high, these are people who…
Category: Tuberculosis (TB)
Explainer: What makes the new drug-resistant TB medicine Pretomanid promising
When used in combination with bedaquiline and linezolid, the newly approved pretomanid drug for MDR-TB and XDR-TB had an overall treatment success rate of about 90%. Besides better effectiveness, the…
Tweaked pharmacy referral model increases TB case-finding in Patna
Tweaking the existing pharmacy referral system in Patna brought huge benefits. Instead of referring symptomatic TB patients to doctor for consultation, referring them for an X-ray before consulting a doctor…
IGIB unravels a new mechanism TB bacteria use to subvert host defence
IGIB researchers have found that besides degradative pathways, TB bacteria actively manipulate another organelle — lipid droplets in macrophages. When lipid droplets are infected with TB bacteria, the composition of…
Delhi researchers find diabetic drug improves the efficacy of two TB drugs
Delhi researchers have identified a protein that is vital for the formation of biofilm by TB-causing bacteria and other bacterial species. Two FDA-approved drugs (acarbose and cyclosporine-A) bind to the…
Podcast: New diagnostic tests for TB
Tarun Sharma explains how the team developed highly sensitive and specific diagnostic tests for pulmonary TB and pleural TB. The diagnostic tests make use of a DNA aptamer that shows high…
AIIMS-led team develops sensitive diagnostic tests for TB
Researchers have developed highly sensitive and specific diagnostic tests for pulmonary TB and pleural TB. The diagnostic tests make use of a DNA aptamer that shows high binding affinity to a…
‘Unethical to withhold bedaquiline treatment while waiting for Phase III results’
In a Phase IIb trail, bedaquiline drug for MDR-TB treatment was found to be cardiotoxic and hepatotoxic, and it also caused more deaths. Review of evidence in 2015 showed a…
