Will adenovirus antibodies reduce the efficacy of vector vaccines?

While it is unclear if pre-existing antibodies to adenovirus vector will affect vaccine efficacy, it is possible that repeated vaccination using adenovirus-based vaccine either as a booster or as annual vaccination, if the need arises, will result in reduced efficacy due to vector immunity.

India eradicated wild polio virus but at what cost

Despite oral polio vaccine causing vaccine-derived poliovirus (VDPV) and vaccine-associated paralytic poliomyelitis (VAPP) cases, India did not switch over from OPV to inactivated polio vaccine (IPV). While circulating VDPV strains are tracked, and outbreaks and cases recorded, little is known about VAPP cases. The justification that VAPP cases are “sporadic and pose little or no … Continue reading India eradicated wild polio virus but at what cost

Polio: Off-label use of IPV vaccine to tide over shortage

Due to shortage of Inactivated Polio Vaccine (IPV) globally, India and a few other countries are stretching the supply of the vaccine to cover all children. The IPV vaccine was introduced into the routine immunisation programme in India from November 30, 2015. To tide over the shortage, children in Puducherry and seven States (Andhra Pradesh, … Continue reading Polio: Off-label use of IPV vaccine to tide over shortage

Global ‘switch’ to reduce vaccine-derived polio cases

Beginning Monday, April 25, India will stop using the oral polio vaccine (OPV) with all three strains of the poliovirus (type 1, type 2 and type 3) and instead use OPV vaccines with only two strains — type 1 and type 3. The global vaccine “switch”, from trivalent to bivalent OPV, has been recommended by … Continue reading Global ‘switch’ to reduce vaccine-derived polio cases

Pakistan’s polio plan needs global support

After a year of relative success, the polio eradication drive in Pakistan received a setback on Wednesday (January 13) when a blast near a polio vaccination centre in Quetta killed at least 15 people and injured nearly two dozen others. The Pakistani Taliban and Jundullah have claimed responsibility for the attack. In recent years, militants have … Continue reading Pakistan’s polio plan needs global support

IPV vaccine boost to India’s polio fight

After nearly five polio-free years, and with the launch of the inactivated polio vaccine (IPV) injection in the national immunisation programme tomorrow (November 30), India will be pushing for “endgame polio”. The injectable vaccine, which uses killed polio viruses, will be used alongside the oral polio vaccine (OPV). For now, immunisation using IPV will be … Continue reading IPV vaccine boost to India’s polio fight

‘We are fighting a war against polio without a General’

A 10-month-old baby in Beed district, Maharashtra who was recently diagnosed of polio caused by the vaccine-derived poliovirus (VDPV) type 2 turns the spotlight on the shortcomings of using a live, weakened polio virus in oral polio vaccine. Dr. T. Jacob John, member of the WHO committee on global polio eradication, in an email to … Continue reading ‘We are fighting a war against polio without a General’

Bring in injectable polio vaccine

A 10-month-old baby in Beed district, Maharashtra who recently got infected by a vaccine-derived poliovirus (VDPV) type 2 is yet another reminder that despite India being declared polio free more than two years ago, children are getting infected with the polio virus. The only difference is that the virus in question is not the wild … Continue reading Bring in injectable polio vaccine

A vaccine boost to India’s polio fight

Published in The Hindu on November 29, 2015 After nearly five polio-free years, and with the launch of the inactivated polio vaccine (IPV) injection in the national immunisation programme tomorrow (November 30), India will be pushing for “endgame polio”. The injectable vaccine, which uses killed polio viruses, will be used alongside the oral polio vaccine … Continue reading A vaccine boost to India’s polio fight