A NII-led team has unravelled how C. elegans exposed to early-life, moderate stress in the form of dietary restriction are able to better handle chronic stress that comes with ageing and thereby increase longevity. The small stress also helps delaying certain age-onset diseases such as Huntington’s and Alzheimer’s. The role of dietary restriction in delaying … Continue reading NII unravels how diet restriction delays ageing, increases lifespan
C. elegans
Podcast: Increasing the longevity of C. elegans
Arnab Mukhopadhyay explains how the longevity of C. elegans was increased 40-60% by using a gene-diet pairing in a mutant. The lifespan increased even when there was no restriction on the quantity of food consumed. The understanding of gene-diet pairings is important as it will give researchers a handle to engage a targeted approach to regulate lifespan.
Mutant worms live 60% longer on specific diet
The longevity of C. elegans increased 40-60% when NII researchers used a mutant that lacked the function of a particular gene and fed the worm a specific bacterial diet — E. coli strain H. The lifespan increased even when there was no restriction on the quantity of food consumed. The understanding of gene-diet pairings is important as … Continue reading Mutant worms live 60% longer on specific diet
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